Granulosa cell tumor of the ovary requires regular, long. Definition, etiology, and evaluation of precocious puberty. Clinicopathologic features of ovarian sertolileydig cell tumors. Very few case reports have been documented in the literature so far. A rare type of ovarian tumor which can cause excess estrogen hormone production. This is a retrospective study of patient data originally collected between january 2003 and december 2010. Recently i have be diagnosed with granulosa cell tumor of the ovary.
In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant gct. Granulosa cell tumor of the ovary symptoms, diagnosis. Hormonal treatment of a recurrent granulosa cell tumor of. The followup data were collected from the hospital files, the patients private physicians, and the norwegian cancer registry.
Histologically, these neoplasms belong to the category of sexcord stromal tumors, comprising 70% of tumors in this group 1 x 1 schumer, s. We are not able to provide medical advice or cancer specialist referrals. Get a printable copy pdf file of the complete article 1. Sertolileydig cell tumor of ovary is a rare type of sexcord stromal tumor. Pdf prognostic factors in adult granulosa cell tumors of the ovary. It is an uncommon primary malignant tumor of the ovary and represents 2 % to 5% of all ovarian cancers 1. The majority of the cases occur in young women and are benign and unilateral in location. Granulosa cell tumor gct of the ovary is a relatively rare cancer, accounting for only 35% of all ovarian malignancies. A total of 27 patients were diagnosed with granulosa cell tumors during that time period by the department of clinical oncology, in the national institute of oncology based in rabat, morocco. Juvenile granulosa cell tumour is a similar but distinct rare tumour. The records of all patients were analyzed to determine clinical presentation, treatment, survival, and prognostic factors. Ct and mri findings of sex cordstromal tumor of the ovary.
Sertolileydig cell tumor of the ovary in a young female. Recurrence of granulosa cell tumour after thirty years. Granulosa cell tumor of the ovary genetic and rare diseases nih. All cases of ovarian tumors during the period from may 20 to june 2015 were retrieved from the record files and analyzed. I would like to hear and talk to other people who have this same type of cancer. Ovarian granulosa cell tumor gct is a malignant tumor with slow progression. For language access assistance, contact the ncats public information officer. Ovarian granulosa cell tumor gct is a malignant tumor originating from the sexcord stromal cells of the ovary. The granulosa cell tumor of the ovary foundation gctf exists to raise funds for granulosa cell tumor of the ovary gct, ovarian cancer research.
These tumours characteristically have a low malignant potential, and a tendency for local spread and high recurrence rates, sometimes many years after the original diagnosis 2, 3. Granulosa cell tumor of the ovary clinical trials, 7 results, page 1. Case report adolescent nongestational ovarian choriocarcinoma. Granulosa cell tumor hormonal aspects and radio sensitivity. We present two patients with malignant ovarian adult gct. Ketoconazole as inhibitor of the enzyme cyp17 in locally advanced or disseminated granulosa cell tumour of ovary. Ovarian stertoliledig cell tumor slct is a rare type of sex cordstromal tumor of the ovary. Unlike epithelial ovarian tumors, they occur in a younger age group, are usually detected in an early stage and often have. The granulosa cell tumor gct is a rare ovarian neoplasm accounting for approximately 3% of all ovarian malignancies1. Pdf this report presents the case of a late relapse of an ovarian granulosa cell tumor gct that metastasized to the lung 36 years after the. Full text full text is available as a scanned copy of the original print version. Granulosa cell tumor is a type of stromal tumor affected at the sex cord of the ovary 1,2. If you have problems viewing pdf files, download the latest version of adobe reader. A retrospective study of 118 cases of granulosa cell tumor of the ovary with a followup from 5 to more than 30 years was made.
Granulosa cell tumor is a slowgrowing cancer that starts in the granulosa cells that surround the eggs within the ovary. We describe a case of granulosa cell tumour of the ovary, which. From the department of obstetrics and gynecology, university of wisconsin n the 45 cases of malignancy of the ovary proved by microscopic examination at the wisconsin general hospital during the past eight years, five have been granulosa cell tumors. Pathology outlines leydig cell tumor hilus cell tumor. Get a printable copy pdf file of the complete article 3. Im a 43 year old woman, just diagnosed with granulosa cell tumor of the ovary. This tumor is classified into juvenile gct and adult gct, and the majority of the cases are the adult type.
Oc is a group of malignant germ cell tumors of the ovary derived from embryonic gonad pri mordial germ cells. Pdf lung metastasis from an ovarian granulosa cell tumor 36. The recurrence of granulosa cell tumor often happens after 5 years, leading to a forgotten tumor by the patient. However, high umbilical cord serum concentrations brenner tumors, lipoid cell tumors of the ovary, sclerosing stromalcell tumors, and adrenal tumors. A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for granulosa cell tumor of the. In the testis it is extremely rare, and has not been reported to be malignant. Adult granulosa cell tumor gct is a rare ovarian malignancy having good prognosis in comparison with other epithelial tumors. Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. Analysis of germ cell tumors of ovary in a tertiary care hospital.
Sex cordstromal tumors of the ovary are rare ovarian neoplasms, which arise from stromal cells and primitive sex cords in the ovary. It is an uncommon primary malignant tumor of the ovary and represents 2% to 5% of all ovarian cancers. More detailed information about the symptoms, causes, and treatments of granulosa cell tumor of the ovary is available below. Poorly differentiated ovarian sertolileydig cell tumor in. Granulosa cell tumors of the ovary with precocious puberty. Pdf ovarian granulosa cell tumors are rare malignancies with a relatively favorable prognosis. The common types are granulosa cell tumors, fibrothecomas, sclerosing stromal tumors, and sertolileydig cell tumors.
A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with. Rare, derived from hilar cells almost always benign call a nonhilar leydig cell tumor if it occurs in ovarian cortical stroma symptoms. Sertolileydig cell tumor slct of the ovary is an exceedingly unusual neoplasm that belongs to a group of sexcordstromal tumors of ovary and accounts for methods. Granulosa cell tumors constitute less than 5 % of all ovarian tumors. Full text get a printable copy pdf file of the complete article 5. Herein, we report a case of primary poorly differentiated ovarian sertolileydig cell tumor slct involving the left ovary. Using the world health organization histologic classification of ovarian tumors, histologic features for common and rare human ovarian tumors are described and illustrated. Prevalence almost 2 to 5 percent of ovarian neoplasms are mainly granulosa cell tumor.
After surgery to remove the 5cm cyst and my right ovary i was staged at 1c cyst ruptured during surgery the gynonc has suggested to remove the other ovary but after a lot of research im wondering wether i should be doing a full hystorectomy, as well as more therapy. However, gct of the ovary requires regular and longterm followup with a doctor, including an annual blood test to check for markers that could indicate the cancers return. A pink tumor shows cystlike areas with occasional nodules at low power. Sertolileydig cell tumor slct of ovary is an exceedingly unusual neoplasm that belongs to a group of sex cordstromal tumors of ovary and accounts for less than 0. Epithelial carcinoma of the ovary, fallopian tube, and peritoneum. It is the most common 70% sex cord stromal tumor and the most common 80% hormoneproducing ovarian tumor25. This seems to be a very rare type of ovarian cancer. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Only few case reports are published in the literature.
Granulosa cell tumours are uncommon sex cordstromal tumours of the ovary, and comprise approximately 3% of all ovarian malignancies. From the files of the dutch ovarian tumor committee 31 granu losa theca cell. There is also a private facebook group of almost 600 women diagnosed with gct called gct survivor sisters that you can request to join. This type of tumor is known as a sex cordstromal tumor and usually occurs in adults. Diagnosed and treated early, its not likely to return. Granulosa cell tumors gcts of the ovary account for 2 to 5 of ovarian malignancies. In the other, an aromatase inhibitor was effective for recurrent malignant gct. Granulosa cell tumors gct of the ovary are composed of gra nulosa cells with or. The cysts are in fact follicles, some producing, as here, the typical basophilic fluid. Tumor cells haphazardly spread without longitudinal grooves, with small nucleoli, in an edematous background. Ovarian tumor markers ovary, fallopian tube, primary peritoneal carcinoma tnm, 8th ed steps in staging ovarian cancer bleomycin etoposide and cisplatin regimen ovar granulosa cell tumor progn related topics. Although this tumour usually occurs in children hence its name, it has been reported in adults. Surgery should be by an open procedure to enable removal of the affected ovary with its tumour intact rather than broken or ruptured. If you are facebook, there is a page for the granulosa cell tumor foundation in new zeland.
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